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KMID : 1036020200090030419
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지질.동맥경화학회지
2020 Volume.9 No. 3 p.419 ~ p.434
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The Key Role of DNA Methylation and Histone Acetylation in Epigenetics of Atherosclerosis
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Lee Han-Teo
Oh Sang-Hyeon
Ro Du-Hyun
Yoo Hye-Rin
Kwon Yoo-Wook
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Abstract
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Atherosclerosis, which is the most common chronic disease of the coronary artery, constitutes a vascular pathology induced by inflammation and plaque accumulation within arterial vessel walls. Both DNA methylation and histone modifications are epigenetic changes relevant for atherosclerosis. Recent studies have shown that the DNA methylation and histone modification systems are closely interrelated and mechanically dependent on each other. Herein, we explore the functional linkage between these systems, with a particular emphasis on several recent findings suggesting that histone acetylation can help in targeting DNA methylation and that DNA methylation may control gene expression during atherosclerosis.
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KEYWORD
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DNA methylation, Histones, Acetylation, Atherosclerosis
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